Generalized periodontitis with no risk for endothelial dysfunction Oral Health
Conditions
Interventions
This was a 6-month, randomized controlled trial, including 140 patients between 41 and 63 years old, diagnosed with severe periodontitis, free from cardiovascular disease (CVD), and traditional cardio
Sponsors
University of Bari Aldo Moro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 41 years old and 63 years old 2. Diagnosis of generalized periodontitis
Exclusion criteria
Exclusion criteria: 1. Patients presenting with dental implants, orthodontic bands and ulcers 2. Patients who received periodontal treatment within 12 months prior to the start of the study 3. Patients who received systemic antibiotics within the last 6 months 4. Pregnancy or breastfeeding mothers 5. History of diabetes or a fasting glucose level greater than 126 mg/dl 6. History of cardiovascular disease 7. Patients with any systemic disease: 7.1. Diabetes mellitus 7.2. Cardiovascular disease 7.3. Kidney disease 7.4. Liver disease 7.5. Lung disease 8. Patients with cardiovascular risk factors and active smokers were excluded to minimize any confounding effect of conditions that may influence endothelial function
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asymmetric dimethylarginine levels in blood measured by enzyme-linked immunosorbent assay (ELISA, DLD Diagnostika, Hamburg, Germany) at baseline, 3 and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Fibromuscular dysplasia (FMD) of the right brachial artery measured using ultrasound at baseline, 3 and 6 months 2. Periodontal indices using a periodontal probe at baseline, 3 and 6 months | — |
Countries
Albania
Outcome results
None listed