Parkinson's disease Nervous System Diseases Parkinson disease
Conditions
Interventions
Patients are blindly allocated to the following two groups by drawing lots. In order to balance the allocation of patients to both treatment conditions, lots are drawn per 4 patients (i.e. 2 experimen
goal setting and planning
and initiative and regulation. Patients are taught several strategies that can be applied to a broad range of daily life situations.
2. Control treatment - Cogniplus: computerized cogn
Sponsors
Dutch Organization for Scientific Research (NWO), the National Initiative Brain and Cognition (NIHC)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with idiopathic Parkinson's disease according to the UK Parkinson’s Disease Brain Bank Criteria, with disease severity = Hoehn & Yahr (H&Y) stage 3 2. Age range 18-80 years 3. Patients had to be motivated for treatment 4. Patients had to report problems with EF in daily life that were experienced as burdensome (based on semi-structured interview and/or a total score of =18 on the Dysexecutive Questionnaire (DEX) and/or showed impairments on objective neuropsychological tests of executive function (EF): 4.1. A standard score of =2 on the subtests Zoo Map Test or Six Elements Test of the Behavioural Assessment of the Dysexecutive Syndrome (BADS) and/or 4.2. A standard age total score on the BADS categorized as “low average” or lower and/or 4.3. A discrepancy of 15 points between standard age score and premorbid IQ as measured with the short version of the Dutch Groninger Intelligence Test 5. Patients had to speak and understand the Dutch language
Exclusion criteria
Exclusion criteria: 1. Severe neurological comorbidity, such as traumatic brain injury or stroke 2. Severe psychiatric symptoms, such as hallucinations, delusions or depression 3. Severe cognitive comorbidity: e.g. amnestic syndrome, global aphasia, neglect, severe memory problems, PD dementia (i.e. SCales for Outcomes in PArkinson’s disease-COGnition scale score =17) 4. Hoehn & Yahr stage 4 and 5
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patients’ level of participation in different societal domains (i.e. work, social relations, leisure activities and mobility), measured using the Role Resumption list (RRL) at baseline, two weeks post-treatment and at 3-5 months follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured at baseline, 2 weeks post-treatment and at 3-5 months follow-up: 1. Attainment of three individual executive goals set by patients during the third session of ReSET or Cogniplus, measured using the Treatment Goal Attainment scale 2. Problems in executive functioning in daily life, measured using the Dysexecutive Questionnaire, completed by participants and someone who had a good insight into the patients’ functioning in daily life 3. Quality of life, measured using the Parkinson's Disease Questionnaire (PDQ-39) 4. Behavioural functioning, measured using executive subscales of the Brock Adaptive Functioning Questionnaire (BAFQ) (participant and significant other ratings) 5. Caregiver burden, measured using the Zarit Burden Interview 6. Executive functions (planning skills, inhibition, abstract reasoning, problem solving and estimation of time), measured using the Behavioural Assessment of the Dysexecutive Syndrome (BADS) 7. Selective attention and attentional switching or cognitive flexibility, measured using the Test of Everyday Attention (TEA) | — |
Countries
Netherlands
Outcome results
None listed