Nutritional intake Nutritional, Metabolic, Endocrine
Conditions
Interventions
The study visits will take place at the NIHR/Imperial Clinical Research Facility at Hammersmith Hospital or the Hugh Sinclair Unit of Human Nutrition at the University of Reading and will include two
Sponsors
Imperial College London
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 – 70 years 2. Body Mass Index (BMI) 20-30 kg/m²
Exclusion criteria
Exclusion criteria: 1. Have been involved in any other study during the previous 12 weeks, are not able to commit to the study (e.g., travel commitments) or are unwilling to collect urine and blood samples and wear the micro-camera 2. Had a weight change of more than 3kg in the preceding 3 months or are currently following a weight-loss diet 3. Have excess alcohol intake (more than 21 units per week) (e.g., a medium glass of wine = 2.3 units) 4. Are unwilling to abstain from drinking alcohol and avoiding strenuous exercise during the two 5-day test periods 5. Are unwilling to follow the study menus (e.g., dislike of food items, following a restrictive/specialised diet or receiving specialised dietary advice for a medical condition); participants will not be permitted to eat/drink anything else during the two 5-day test periods 6. Are not able to eat fish and/or meat (e.g., are vegan or vegetarian) 7. Have an allergy/intolerance to any of the food items in the menu 8. Have taken any dietary supplements in the last 3 months (e.g., multivitamins, fish oils) 9. Are pregnant or lactating 10. Currently, suffer from any of the following: eating disorders, diabetes, cancer, gastrointestinal disorders (e.g., inflammatory bowel disease or irritable bowel syndrome), kidney disease, liver disease, pancreatitis, HIV or AIDS or any other chronic illness 11. Are taking any of the following medications: anti-inflammatory drugs or steroids, antibiotics, androgens, phenytoin, erythromycin, or thyroid hormones 12. Use illicit substances 13. Have been diagnosed with dementia or other conditions affecting memory 14. Have difficulty using laptops/tablets (e.g., cannot use these devices without assistance, are blind or have other conditions affecting sight, or have physical disabilities/conditions that affect your ability to press buttons) 15. Cannot read and understand English
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The accuracy of dietary reporting will be measured at the end of each intervention week using dietary data collected from wearable micro cameras, spot urine samples, capillary blood samples, and self-report dietary recalls. Total daily consumption (grams per day) will be reported by wearable micro cameras and self-report dietary recalls. Liquid chromatography-mass spectrometry (LC-MS) will measure biomarkers of dietary components in spot urine samples and capillary blood samples and daily dietary intake will be reported using µg/ml concentrations of dietary exposure biomarkers. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Creation of a multiplatform model of dietary intake using g/day measured from wearable micro-cameras and self-report dietary recalls, and µg/ml of dietary exposure biomarkers from spot urine samples and capillary blood samples at the end of the study 2. Design a dietary intake study informed by the results of the dietary intake study protocol in a free-living population at the end of the study | — |
Countries
England, United Kingdom
Contacts
Public ContactMichelle;Katerina Weech;Petropoulou
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Outcome results
None listed