Maternal-fetal effects of metabolism in pregnancy Pregnancy and Childbirth Maternal-fetal effects of metabolism in pregnancy
Conditions
Interventions
Participants attend study visits at three time points in pregnancy (approximately at 12, 26, and 34 gestational weeks) during which maternal blood, questionnaire data on lifestyle, and anthropometry a
Sponsors
Lund University
Skåne University Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: In total, we will recruit around 30 pregnant women: 1. Aged 25-35 before gestational week 12+6 Half of the recruited women (50%) will have a high risk of gestational diabetes mellitus: 1. Family history of diabetes 2. Prior pregnancy affected by diabetes 3. Current obesity Half of the recruited women (50%) are expected to have a normal pregnancy not complicated by gestational diabetes mellitus (controls). If a control woman develops gestational diabetes, she will be invited to continue to take part in the study and be monitored as per standard of care; we will then seek to recruit an additional woman to the control arm to ensure an adequate number of participants in the study.
Exclusion criteria
Exclusion criteria: 1. Not of Scandinavian origin 2. Use of assisted reproductive technology 3. History of three or more first trimester miscarriages 4. Tobacco use (smoking/snus) in the previous three months 5. Diagnosed PCOS 6. History of gastric bypass surgery 7. Type 1 diabetes 8. Non-Swedish speaker 9. Planned termination of pregnancy or planning to give up infant for adoption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in fetal/placental DNA methylation at three time points in pregnancy are measured using cell-free fetal DNA isolated from maternal blood and next generation sequencing at approximately 12, 26, and 34 gestational weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Maternal physical activity as measured by wrist accelerometer from early pregnancy to delivery 2. Maternal blood-glucose as measured by a continuous glucose monitor and OGTT from early pregnancy to delivery 3. Maternal weight gain and body composition (daily weighing using a medical scale and/or clinically measured using the Styku 3D body scanning system) throughout pregnancy and postpartum | — |
Countries
Sweden
Contacts
Public ContactAngela Estampador
Outcome results
None listed