Knee osteoarthritis Musculoskeletal Diseases
Conditions
Interventions
A two-stage study is proposed. Firstly, we will perform analysis of factors associated with poor outcome to develop a screening algorithm. Methods to identify people at high risk are uncertain, but ge
those in the intervention arm will receive a home-based exercise programme. We will measure patients’ progress at 6 months and one year after their surgery.
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Participant is willing and able to give informed consent for participation in the study 2. Male or female, aged 55 years or above 3. Primary unilateral KR as a scheduled procedure 4. Deemed by study screening tool developed to be at risk of poor outcome 5. Happy to allow physiotherapy teams to attend their home to deliver the intensive rehabilitation programme if randomised to the intervention arm
Exclusion criteria
Exclusion criteria: 1. Any absolute contraindications to exercise 2. Severe cardiovascular or pulmonary disease (New York Heart Association III-IV) 3. Severe dementia, assessed using the hospital dementia screening tool 4. Rheumatoid arthritis 5. Further lower limb arthroplasty surgery planned within 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Late Life Function and Disability Instrument (LLFDI) score, collected at baseline, 6 and 12 months after randomisation. Primary endpoint:12 months post-surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Current secondary outcome measures as of 25/06/2021: Questionnaires and physical measures at baseline, 6 months, and 12 months unless otherwise indicated: 1. Functional Co-morbidities Index (baseline measure only) 2. Oxford Knee Score 3. Physical Activity Scale for the Elderly (PASE) 4. EQ-5D-5L 5. KOOS, Quality of Life Sub-scale 6. Figure of 8 walk test where participants are asked to walk in a figure of 8 around two cones. This test is timed, the number of steps taken is counted, in addition to accuracy (if a participant stays with in boundary of the test) being recorded. 7. 30 Second Chair Stand Test where the participant starts sitting on a chair which has a seat high of 17 inches, the participant is asked to complete as many full stands in 30 s, the participant sits in between each stand. The number of full stands a person can complete is recorded. 8. Single leg stance where the participant is asked to stand and lift one leg without using any other support, they will be timed standing on one leg. The participant will be stood with a chair in front of them should they require support. Previous secondary outcome measures: Questionnaires at baseline, 6 months and 12 months: 1. Oxford Knee Score 2. Physical Activity Scale for the Elderly (PASE) 3. EQ-5D-5L 4. Functional Co-morbidities Index Physical measures at baseline, 6 months and 12 months: 1. Figure of 8 walk test - participants are asked to walk in a figure of 8 around two cones, this is timed, the number of steps taken is counted, in addition to accuracy (if a participant stays with in boundary of the test) being recorded. 2. 30 Second Chair Stand Test - the participant starts sitting on a chair which has a seat high of 17 | — |
Countries
England, United Kingdom
Outcome results
None listed