A study of multidrug resistant organisms in the adult intensive care unit at Addenbrooke's Hospital

Whole-genome sequencing to investigate colonisation and transmission of multidrug-resistant organisms in the adult intensive care unit at Addenbrooke’s Hospital

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN13493757

Enrollment

400

Registered

2020-02-20

Start date

2016-06-20

Completion date

Unknown

Last updated

2020-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surveillance for multidrug-resistant organisms Infections and Infestations

Interventions

All patients admitted to ICU during the study period will be screened for MDRO and clinical data on infections and antimicrobial use will be collected. Participants will be screened f

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years old or older 2. Male or female 3. Admitted to the John Farman Intensive Care Unit during the study period

Exclusion criteria

Exclusion criteria: Does not fulfil study inclusion criteria

Design outcomes

Primary

Measure	Time frame
Measured using patient records during the study period: 1. Number of patients colonised with multidrug-resistant organisms 2. Number of patients with clinical evidence of infection with multidrug-resistant organisms 3. Number of transmission events of multidrug-resistant organisms	—

Secondary

Measure	Time frame
Measured using patient records during the study period: 1. Risk factors for colonisation / infection with multidrug-resistant organisms 2. Outcome of patients colonised / infected with multidrug-resistant organisms 3. Cost-consequences of whole-genome sequencing versus standard epidemiological investigation / typing for surveillance and investigation of suspected outbreaks and the management of confirmed outbreaks	—

Measure

Time frame

Measured using patient records during the study period: 1. Risk factors for colonisation / infection with multidrug-resistant organisms 2. Outcome of patients colonised / infected with multidrug-resistant organisms 3. Cost-consequences of whole-genome sequencing versus standard epidemiological investigation / typing for surveillance and investigation of suspected outbreaks and the management of confirmed outbreaks

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026