Relationship between birth weight, early growth patterns and cardiovascular disease risk on adult cardiac structure and function in Asian Indians

Childhood and young adult predictors of myocardial structure and function at age 45 years in the New Delhi and Vellore Birth Cohorts, India

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN13432279

Enrollment

3700

Registered

2017-06-05

Start date

2016-11-01

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular disease, Type 2 diabetes, Obesity Circulatory System Cardiovascular disease, Type 2 diabetes, Obesity

Interventions

The current study is an observational study that involves two birth cohorts (New Delhi and Vellore Birth Cohort) in India. Both the cohorts were established during 1969-1972. About 18,000 babies born

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Males and females 2. Aged over 40 years 3. Previously participated in the New Delhi and Vellore Birth Cohorts

Exclusion criteria

Exclusion criteria: Individuals with history or on active treatment for chronic kidney disease or cancer.

Design outcomes

Primary

Measure	Time frame
1. Left ventricular mass and indices of left ventricular systolic and diastolic function assessed by echocardiography at study visit 2. Carotid intima media thickness assessed using ultrasound at study visit 3. Ischemic changes in the heart as assessed by electrocardiogram (ECG) at study visit	—

Secondary

Measure	Time frame
1. Body composition as assessed by anthropometry, bioimpedance and dual energy X-ray absorptiometry (DXA) at study visit 2. Glucose intolerance and lipid disorders as assessed by biochemical tests at study visit 3. Socio-economic status as assessed by Standard of Living questionnaire at study visit 4. Dietary pattern as assessed by Food frequency questionnaire at study visit 5. Physical activity as assessed by Global Physical Activity Questionnaire (GPAQ) at study visit 6. Birth weight and early growth data (already collected during previous follow-ups and available in cohort database) at study visit	—

Measure

Time frame

1. Body composition as assessed by anthropometry, bioimpedance and dual energy X-ray absorptiometry (DXA) at study visit 2. Glucose intolerance and lipid disorders as assessed by biochemical tests at study visit 3. Socio-economic status as assessed by Standard of Living questionnaire at study visit 4. Dietary pattern as assessed by Food frequency questionnaire at study visit 5. Physical activity as assessed by Global Physical Activity Questionnaire (GPAQ) at study visit 6. Birth weight and early growth data (already collected during previous follow-ups and available in cohort database) at study visit

—

Countries

India

Contacts

Public ContactSenthil Vasan

Senthil.vasan@ocdem.ox.ac.uk+44 75 75323737

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 24, 2026