Management of antibiotic use within hospital settings. Not Applicable
Conditions
Interventions
Current interventions as of 02/11/2022:
The ePAMS+ Feasibility trial to assess the feasibility of embedding the ePAMS+ intervention and extracting trial outcome measures using administrative data with
Sponsors
University of Edinburgh
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Medical records: 1. Adults >=16 years admitted to hospital as in-patients 2. Patients being treated with antibiotics (identified as Antibiotic Order Plans initiated and/or existing antibiotic use flagged within the electronic prescribing system)
Exclusion criteria
Exclusion criteria: Medical records: 1. Children <16 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Total antibiotic consumption measured as the number of defined daily doses (DDD), assessed overall and at site/ward level 2. Completeness of data extracted and whether standardised queries to capture data from Cerner systems are feasible/assessed via monthly data extracts 3. Assessment of the feasibility of measuring defined outcomes using extracted data | — |
Secondary
| Measure | Time frame |
|---|---|
| Mapping of critical decision points within Cerner systems to core principles of the intervention to develop fidelity index items, and determine how standardised queries to capture data from Cerner will enable coding of item response options (e.g. 'present', 'absent but should be present', 'not applicable') for automation of this coding structure for the cluster-randomised trial The following outcomes will be assessed for feasibility (added 16/05/2022): Length of hospital stay Days of therapy (and intravenous therapy) Diagnostics Number of antibiotics prescribed Number of antibiotic courses Repeat courses for same indication Number of courses for same indication Switches - of frequency - of dose - from intravenous to oral - from oral to intravenous - to alternative antimicrobial - from narrow to broad spectrum Discontinuation of therapy Number of courses concordant with local guidelines for antibiotic choice/duration Resistance rates Susceptibility Acquisition of multi-drug resistant organism Healthcare-associated infection Episodes of - Clostridium difficile infection (CDI) - methicillin- resistant Staphylococcus aureus (MRSA) - gram-negative bacilli (GNB) Added 01/11/2022: Site staff ePAMS+ training information will be captured on the Learning Management System to assess completion of training (i.e. professional discipline, date/time of module completion, time spent on learning and pre and post-test scores) | — |
Countries
England, United Kingdom
Contacts
Public ContactChristopher J Weir
Outcome results
None listed