The efficacy of dexamethasone in mechanically ventilated children with lower respiratory tract infection caused by respiratory syncytial virus (RSV)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13421709

Enrollment

230

Registered

2005-12-01

Start date

2003-11-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory syncytial virus lower respiratory tract infection Respiratory Respiratory syncytial virus

Interventions

Dexamethasone 0.15 mg/kg/dose every 6 hours, 8 doses in total (i.e. 2 days) or placebo (normal saline) 2004 protocol version 5/5 in http://www.star-trial.com/files/STARprotocol_aug04.pdf

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Children younger than 2 years of age 2. Microbiologically proven RSV lower respiratory tract infection 3. Mechanical ventilation

Exclusion criteria

Exclusion criteria: 1. Corticosteroid use within 2 weeks before inclusion 2. No informed consent from parents or caretakers

Design outcomes

Primary

Measure	Time frame
Duration of mechanical ventilation	—

Secondary

Measure	Time frame
1. Length of stay in paediatric intensive care unit (PICU) 2. Length of stay in hospital 3. Duration of supplemental oxygen therapy	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026