Postprandial triglyceride metabolism in response to different rates of sugar (glucose and fructose) consumption in healthy adults. Nutritional, Metabolic, Endocrine
Conditions
Interventions
This is an open-label, randomised, three-condition crossover trial conducted in healthy adults. Participants will complete three experimental conditions in random order, separated by a four-week washo
Sponsors
University of Bristol
University of Bath
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-65 years 2. Body mass index (BMI): 18.5-29.9 kg/m²
Exclusion criteria
Exclusion criteria: 1. Weight instability (greater than 5 kg change in body mass within the last 6 months) 2. Diagnosis of any form of diabetes 3. Intolerances or allergies to any study procedures (e.g., lactose intolerance, egg allergy) 4. Fructose malabsorption 5. Inborn errors of fructose metabolism (e.g., fructokinase deficiency, aldolase B deficiency, fructose-1,6-bisphosphatase deficiency) 6. Pregnant or lactating 7. Any condition that could introduce bias to the study (e.g., lipid disorders including cardiovascular disease, or therapies that alter lipid or glucose metabolism such as statins or niacin) 8. Following a vegan diet, as participants must consume a high-fat meal composed of animal products with the test drink 9. Recent involvement (within the last 6 months) in research that could alter metabolism, or donation of a substantial amount of blood (>470 mL, the standard NHS blood donation) 10. Inability to speak English
Countries
England, United Kingdom
Contacts
Public ContactBenedita Deslandes
Outcome results
None listed