Mild-to-moderate major depressive disorder and depressive symptoms in older adults Mental and Behavioural Disorders
Conditions
Interventions
Participants will be randomly allocated in a 1:1 ratio to either the Baduanjin group or the health education group using a computer-generated randomisation sequence. The randomisation sequence will be
Sponsors
North University of China
Eligibility
Sex/Gender
All
Age
50 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged 50 years or older 2. Meet the DSM-5 diagnostic criteria for major depressive disorder 3. Have mild-to-moderate depressive symptoms, defined as a HAMD-17 score of 15 or above 4. Have no dementia, defined as an MMSE score of 25 or above 5. Have not previously practised Baduanjin or other mind-body exercises before enrolment 6. If receiving antidepressant medication, the medication regimen must have been stable for at least 4 months before enrolment 7. Able and willing to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. History of psychiatric disorders other than major depressive disorder, such as bipolar disorder or schizophrenia 2. Severe or unstable physical disease, such as uncontrolled hypertension, heart failure, or malignant tumours 3. Moderate-to-severe cognitive impairment 4. Participation in other mind-body exercises during the study period, such as Tai Chi, yoga, or Qigong 5. Current participation in another clinical trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in depressive symptoms measured using the 17-item Hamilton Depression Rating Scale (HAMD-17) at baseline, 12 weeks after the intervention, and 1 month after completion of the intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety symptoms measured using the Hamilton Anxiety Rating Scale (HAMA) at baseline, 12 weeks after the intervention, and 1 month after completion of the intervention;Cognitive function measured using Mini-Mental State Examination (MMSE) at baseline, 12 weeks after the intervention, and 1 month after completion of the intervention;Prefrontal relative cerebral blood flow changes measured using diffuse correlation spectroscopy during active tasks, including the verbal fluency task and higher cognitive task. The relative cerebral blood flow change will be calculated as ?rCBF at baseline, 12 weeks after the intervention, and 1 month after completion of the intervention;Recovery slope of prefrontal haemodynamic responses measured using diffuse correlation spectroscopy within 30 seconds after passive challenges, including voluntary breath holding and postural challenge tasks at baseline, 12 weeks after the intervention, and 1 month after completion of the intervention;Adherence and safety measured using using practice diaries and recording adverse events at during the 12-week intervention period and at 1-month follow-up after completion of the intervention | — |
Countries
China
Contacts
Public ContactZhengfei Cheng
Outcome results
None listed