Motor dysfunction after stroke Nervous System Diseases Motor dysfunction after stroke
Conditions
Interventions
Participants who meet the eligibility criteria will be randomly assigned to one of the two groups in a 1:1 ratio. Randomization will be conducted using computer-generated random numbers placed in sequ
Sponsors
Beijing Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. First-ever mono-hemispheric ischemic stroke 2. Within 14 days after stroke onset 3. Hand weakness with MRC level of 1 to 4 4. Aged between 18 and 80
Exclusion criteria
Exclusion criteria: 1. Participation in other medical studies at present or during the previous 3 months 2. Pre-existing conditions of body dysfunction before stroke attack 3. Pregnancy 4. Cognitive or communication impairment or pre-existing conditions precluding informed consent or compliance with study assessments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Excitability of primary motor cortex measured by recruitment curve of Motor Evoked Potential by transcranial magnetic stimulation at baseline and 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Motor function of hand and arm are measured using the Action Research Arm Test and the upper-extremity portion of the Fugl-Meyer motor assessment at baseline and 3 months 2. General motor disability is measured using the modified Rankin scale at baseline and 3 months 3. Neurological deficit is measured using National Institutes of Health Stroke Scale assessment at baseline and 3 months 4. The muscle strength level is measured using the UK Medical Research Council standard at baseline and 3 months | — |
Countries
China
Outcome results
None listed