Effective interventions to improve organ function and prognosis in patients with acute pancreatitis Digestive System
Conditions
Interventions
Randomization was performed using a stratified block design with randomly permuted block sizes, stratified by center, via a computer-generated program. Patients will be randomized to receive thoracic
Sponsors
Sir Run Run Shaw Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 70 years 2. Admitted to the hospital within 72 h of the onset of abdominal pain, diagnosed with acute pancreatitis 3. With organ failure as defined by the sequential organ failure assessment-2(SOFA-2)score for respiration, renal and cardiovascular systems 4. Voluntary participation; signed informed consent required
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women, or those planning pregnancy within 6 months 2. Acute pancreatitis associated with chronic pancreatitis or pancreatic neoplasms 3. Patients who have undergone retroperitoneal percutaneous drainage 4. Post-cardiopulmonary resuscitation status with unresolved neurological dysfunction 5. Patients with a history of severe primary cardiovascular, respiratory, renal, hepatic, hematological, malignant tumor, or immune diseases 6. Patients with contraindications to TEA: those who are allergic to local anesthetics; those accompanied by severe systemic infection, infection at the puncture site, epidural abscess, or central nervous system infection; those with central nervous system diseases such as spinal cord lesions, spinal nerve root lesions, or intracranial hypertension; patients in shock; those with anatomical variations or a history of back surgery related to the epidural space, making TEA impossible; those with coagulation disorders or those who have not met the required withdrawal time for anticoagulant or antiplatelet medications; those with mental illness, severe neurosis, or other conditions that make cooperation impossible. 7. Participation in other interventional clinical studies within the past 3 months 8. Other conditions deemed unsuitable for inclusion by the investigator
Countries
China
Contacts
Public ContactXin;Bao Yu;Fu
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Outcome results
None listed