Bronchiolitis obliterans in allogenic stem cell transplantation patients Respiratory Other specified chronic obstructive pulmonary disease
Conditions
Interventions
All measurement methods, principally N2-MBW, DTG-SBW and, depending on the clinical picture, FeNO, DLCO, FOT, spirometry and body plethysmography, will be carried out by the researchers in accordance
Sponsors
University Hospital Basel
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 18 years and older 2. Patients undergoing allogenic stem cell transplantation
Exclusion criteria
Exclusion criteria: 1. Failure to provide informed consent 2. Patients too ill or unfit to undergo a lung function test 3. Patients who have undergone stem cell transplantation before inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung clearance index (LCI) is measured with the multiple breath washout technique (N2-MBW) before transplantation, monthly for the first year after transplantation and every three months in the second year after transplantation | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured before transplantation, monthly for the first year after transplantation and every three months in the second year after transplantation: 1. Scon and Sacin are measured using single-breath washout measurements 2. Microbiological parameters such as colonization, infection and dysbiosis, measured using oropharyngeal swabs 3. Serum biomarkers of inflammation or extracellular matrix turnover such as collagen formation and degradation molecules, measured using blood samples | — |
Countries
Switzerland
Contacts
Public ContactLeander Gonzalez
Outcome results
None listed