Randomised placebo controlled trial of antihypertensive agents for the prevention of cardiovascular complications of hypertension

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13275753

Enrollment

4396

Registered

2005-09-08

Start date

1982-03-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension Circulatory System Hypertension

Interventions

Amiloride, hydrochlorothiazide compared with placebo

atenolol compared with placebo.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Men and women aged 65-74 at recruitment in 226 general practices in the Medical Research Council's General Practice Research Framework. Systolic blood pressure 160-209 mmHg and diastolic pressure less than 115 mmHg.

Exclusion criteria

Exclusion criteria: Secondary hypertension; already on antihypertensive treatment; accepted indication for antihypertensive treatment; myocardial infarction or stroke within previous three months; impaired renal function; presence of angina, intermittent claudication, diabetes, gout, bronchial asthma, serious intercurrent disease including malignant hypertension.

Design outcomes

Primary

Measure	Time frame
Stroke, coronary events, deaths from all causes.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026