Primary prevention of fractures in the elderly: randomised controlled trial (RCT) of an annual injection of vitamin D in the prevention of hip and other non-vertebral fractures

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13267529

Enrollment

10000

Registered

2004-01-23

Start date

2000-09-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Injury, occupational diseases, poisoning: Musculoskeletal injury Injury, Occupational Diseases, Poisoning Fracture of femur

Interventions

Injection containing 300,000 IU Vitamin D or placebo injection given annually over three years

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 10,000 men and women over 75 years from a general practice population living independently in own homes or sheltered accommodation

Exclusion criteria

Exclusion criteria: 1. History of renal failure or stones 2. Hypercalcaemia 3. Active cancer 4. Medication history of oestrogen or biphosphonate within last 3 years 5. People taking daily oral vitamin supplements containing 400 IU or more of Vitamin D

Design outcomes

Primary

Measure	Time frame
Incidence of hip fractures, non-vertebral fractures, falls	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026