Generalized severe chronic periodontitis Oral Health Generalized severe chronic periodontitis
Conditions
Interventions
All participants present two teeth in different regions of the mouth that require surgical treatment. One of these teeth is randomly selected to undergo open flap debridement with the application of E
Sponsors
Regional Committees for Medical and Health Research Ethics (REK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 25 and 75 years 2. Non-smoking 3. No use of antibiotics over the previous 6 months prior to treatment 4. The presence of one pair of interproximal sites with probing pocket depth (PPD) of 6 mm or more, horizontal and/or vertical bone loss as demonstrated by the probing measurement and radiographic assessments following the initial phase of periodontal treatment 5. Experimental teeth must either have a vital pulp or, if subjected to root canal treatment, be asymptomatic, and without technical remarks 6. Prior to the start of the trial, the patients will give informed consent
Exclusion criteria
Exclusion criteria: 1. Patients with a systemic condition like diabetes mellitus, cancer, HIV, disorders that compromise wound healing, chronic high dose steroid therapy, bone metabolic disease, radiation or immune-suppressive therapy 2. Patients with acute infectious lesions in the area of intended therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokine levels in gingival fluid are measured using the Luminex-200 system (multiplex bead-based immunoassay) at baseline, 7 and 14 days postoperatively. | — |
Countries
Norway
Outcome results
None listed