Binge eating behaviour Not Applicable
Conditions
Interventions
This is a mechanistic study using a mixed within/between subjects design conducted in a single (academic) centre. There is one between-subjects factor (Group) with three levels, and a within-subjects
3) Binge memory reactivation+ sham CBM (BMR + sham
N= 30). The total duration of treatment and follow-up for all study arms was 9 months.
Full details on Open Science Framework website https://osf.io/82c4r/.
Sponsors
University College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-24 2. Binge on food 2 or more times per month 3. Experience a sense of loss-of-control when bingeing
Exclusion criteria
Exclusion criteria: 1. Are pregnant or breastfeeding, or are likely to become pregnant during the study 2. Are currently seeking treatment for binge eating or any other psychiatric condition 3. Suffer from any major psychiatric or physical health disorder 4. Have a family history of any major psychiatric disorder 5. Engage in ‘purging’ e.g. vomiting, use of laxatives or other medications to compensate for bingeing 6. Drink over the daily governmental alcohol allowance more than 4 times per week 7. Use recreational drugs more than once a week 8. Have an unresolved diagnosis of any eating, drug or alcohol use disorder(s) 9. Are diabetic or currently using blood-sugar-control medication 10. Have a BMI of less than 18.5 11. Have high blood pressure 12. Are unable to abstain from drugs and alcohol for 24 hours prior to each session 13. Eat a vegan diet 14. Are not motivated to change the bingeing behaviour 15. Have a permanent hairstyle such as dreadlocks, braids, cornrows that means we will not be able to fit an EEG cap
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Motor approach bias to highly palatable foods as assessed by changes in performance on a food Go/No-Go task from pre-manipulation on Day 1 (baseline) to post-intervention on Day ~14 (test). Approach bias is demonstrated by faster ‘go’ responses and more commission errors to binge food images than low-palatability and control images in a Go/No-Go CBM task. 2. Changes in oculomotor approach to highly palatable foods as assessed by eyetracking in dot-probe/ attentional bias task, performed pre-intervention on Day 1 (baseline) and post-intervention on Day ~14 (test). 3. Binge frequency and daily food consumption. This is logged via an online app (MyFitnessPal). Experimenters will extract frequency of subjective binges and objective consumption information (caloric volume of binge foods and non-binge foods consumed). Outcomes from this measure will thus be 1) frequency of subjective binge episodes in the pre-intervention on Day 1 (baseline) period, post-intervention Day ~14 (test) period and at follow-up periods of ~28 days, 3 months, 6 months and 9 months post-intervention 2) average (mean, or median if high skew is present) corresponding macronutrient intake over these same periods. 4. Binge Eating Scale (BES), a questionnaire-based measure of specific binge eating symptomatology severity is used at pre-intervention on Day 1 (baseline), post-intervention Day ~14 (test) and at follow-up periods of ~28 days, 3 months, 6 months and 9months post-intervention. 5. Eating Disorders Examination-Questionnaire (EDE-Q) is used to assess disordered eating at pre-intervention on Day 1 (baseline), post-intervention Day ~14 (test) and at follow-up periods of ~28 days, 3 months, 6 months and 9 months post-intervention. 6. Food Craving Questionnaire State/Trait (FCQ-T/FCQ-S) will be used to assess momentary craving evoked by exposure to binge food images and in-vivo high-palatability food at pre-interven | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Height/weight and BMI, resting heart rate, blood pressure, and blood glucose are assessed in-lab at Day 1 (baseline), Day 2 (intervention day) and at Day ~14 post-intervention (test) using high-accuracy scales, an Omron heart rate/blood pressure cuff, and through finger-prick glucose oxidase with an SDCheck monitor, respectively. 2. Basic information, Family History of Eating Disorders and Typical Binge Foods List are recorded pre-intervention on Day 1 (baseline). 3. Depression via the Beck Depression Inventory (BDI), Trait Anxiety via the Spielberger Trait Anxiety Index, Trait Impulsivity via the Barratt Impulsiveness Scale (BIS), Trait Behavioural Inhibition and Activation via the BIS/BAS scale, temporal discounting via the Kirby Delay-Discounting Task (DDT), tolerance for distress via the Distress Tolerance Scale, and disgust via the Disgust Propensity and Sensitivity Scale-Revised, are assessed pre-intervention on Day 1 (baseline) and post-intervention on Day ~14 (test). 4. Food Addiction Symptomatology are assessed using the Yale Food Addiction Scale (Y-FAS), Three Factor Eating Questionnaire-revised (TFEQ-r), and the Power of Food Scale (PFS), at pre-intervention on Day 1 (baseline) period, post-intervention Day ~14 (test) period. 5. Calorie consumption and satiety are assessed via a Timeline Follow-Back (TLFB) and Hunger Scale, respectively, at pre-intervention on Day 1 (baseline) and post-intervention on Day ~14 (test). 6. Anxiety via a Visual Analogue scale, and affect via the Positive and Negative Affect Scale are assessed on Day 2 (intervention), pre and post intervention. 7. The YFAS, BES, FCQT, PFS, TFEQ-r, EDE-Q, and TLFB are used again at follow-up periods of ~28 days, 3 months, 6 months and 9 months post-intervention. 8. Electroencephalography (EEG) in response to binge food images. We will assess neural correlates of successful and unsu | — |
Countries
United Kingdom
Outcome results
None listed