Take home naloxone intervention in multicentre emergency settings

Conditions

Opioid overdose Injury, Occupational Diseases, Poisoning Other opioids

Helen Snooks, Jonathan Benger, Fiona Bell, Sarah Black, Simon Dixon et al. (19 authors)

Health Technology Assessment2024-10-01

Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial.

Snooks HA, Jones JK, Bell FB, Benger JR, Black SL, Dixon S, Edwards A, Emery H, Evans BA, Fuller GW, Goodacre S, Hoskins R, Hughes J, John A, Johnston S, Jones MB, Moore CR, Parab R, Pilbery R, Sampson FC, Watkins A.

2024-08-29

10.1186/s12873-024-01061-3

Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study.

Jones M, Bell F, Benger J, Black S, Buykx P, Dixon S, Driscoll T, Evans B, Edwards A, Fuller G, Goodacre S, Hoskins R, Hughes J, John A, Jones J, Moore C, Sampson F, Watkins A, Snooks H.

2020-07-097 citations

10.1186/s40814-020-00626-w

Interventions

This is a feasibility study for an RCT of Take Home Naloxone (THN) in emergency settings clustered by emergency department (ED) catchment area and local ambulance service. Anonymised linked data outco

this reduced the randomisation options to four, as listed below: Option A: Intervention: Wrexham, Sheffield Control: Bristol, Hull Option B: Intervention: Bristol, Hull Control: Wrexham, Sheffield

a protocol for the supply of THN kits to those eligible for the intervention

a single use THN kit (ampoule of Nalo

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Eligible for intervention: Adult (18 years of age or over, male or female) opioid users at risk of overdose who are attended by emergency ambulance paramedic or who attend ED Accompanying friends, relatives or carers (18 years of age or over, male or female) of opioid users at risk of overdose who are attended by emergency ambulance paramedic or who attend ED Eligible for inclusion in outcome follow up and analyses: High risk peers (18 years of age or over, male or female) - opioid users at high risk of fatal opioid overdose who make up a wider peer group who may or may not make contact with emergency services at study site during the study period

Exclusion criteria

Exclusion criteria: 1. Under 18 years of age 2. Actively dissent from involvement in study 3. Non-opioid overdose

Design outcomes

Primary

Measure	Time frame
Mortality (total and opioid overdose related), collected using anonymised data linkage at a single time point 12 months post intervention	—

Secondary

Measure	Time frame
Collected using anonymised data linkage at a single time point 12 months post intervention: 1. Emergency admissions 2. ITU admissions 3. ED attendances (total and opioid overdose related) 4. 999 attendances (total and opioid overdose related) 5. THN kits issued 6. NHS resource usage	—

Countries

England, United Kingdom, Wales

Contacts

Public ContactJenna Jones

j.k.jones@swansea.ac.uk+44 (0)1792513424

Outcome results

None listed