Does resistance training exercise help prevent frailty and loss of independence for older people with insulin treated diabetes? The EXPLODE Trial

EXercise to Prevent frailty and Loss Of independence in insulin treated older people with DiabetEs: The EXPLODE Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13193281

Enrollment

Registered

2020-08-03

Start date

2020-10-01

Completion date

Unknown

Last updated

2023-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 1 diabetes and type 2 diabetes treated with exogenous insulin Nutritional, Metabolic, Endocrine Diabetes mellitus

Interventions

All participants will complete baseline blood and physical testing. Participants will then be randomised (1:1 ratio) to either: 1. Intervention group, a 4-week programme of supervised

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged =60 years 2. Rockwood Clinical Frailty Score of 3 or 4 3. Diagnosis of type 1 or type 2 diabetes mellitus, or age and frailty matched non-diabetic control

Exclusion criteria

Exclusion criteria: 1. Myocardial infarction in the last 12 months 2. Stroke in the last 12 months 3. Renal failure in the last 12 months 4. Liver disease in the last 12 months 5. Inability to give consent

Design outcomes

Primary

Measure	Time frame
Feasibility of carrying out a larger trial, measured using recruitment and retention rate, and the acceptability of intervention of resistance exercise as assessed using an interview of a subset of participants at baseline and 5 weeks	—

Secondary

Measure	Time frame
1. Body composition measured using height, weight, waist circumference, percentage body fat, and percentage fat-free mass using bioelectrical impedance analysis at baseline and 5 weeks 2. Isometric strength measured using a torque and strain gauge at baseline and 5 weeks 3. Handgrip strength measured using a digital handgrip dynamometer at baseline and 5 weeks 4. Gait speed measured using three 4 m walking tests on digital timing gates at baseline and 5 weeks 5. Timed sit to stand, measured using five sit to stand movements at baseline and 5 weeks 6. Cardiovascular health measured using resting blood pressure, HbA1c, blood lipid profile, and inflammatory cytokines at baseline and 5 weeks 7. Wellbeing, activity levels, and (where applicable) views on the resistance training programme and diabetes management, measured narratively using a nested qualitative interview study at baseline and 5 weeks	—

Measure

Time frame

1. Body composition measured using height, weight, waist circumference, percentage body fat, and percentage fat-free mass using bioelectrical impedance analysis at baseline and 5 weeks 2. Isometric strength measured using a torque and strain gauge at baseline and 5 weeks 3. Handgrip strength measured using a digital handgrip dynamometer at baseline and 5 weeks 4. Gait speed measured using three 4 m walking tests on digital timing gates at baseline and 5 weeks 5. Timed sit to stand, measured using five sit to stand movements at baseline and 5 weeks 6. Cardiovascular health measured using resting blood pressure, HbA1c, blood lipid profile, and inflammatory cytokines at baseline and 5 weeks 7. Wellbeing, activity levels, and (where applicable) views on the resistance training programme and diabetes management, measured narratively using a nested qualitative interview study at baseline and 5 weeks

—

Countries

England, United Kingdom

Contacts

Public ContactDaniel;Rachel West;Stocker

;

daniel.west@newcastle.ac.uk;rachel.stocker@newcastle.ac.uk+44 (0)1912087076;+44 (0)1912082057

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 13, 2026