Nasal spray with licorice extract to treat inflammation of the nose and sinuses

Investigating the effect of nasal spray with extract of licorice on treatment of allergic rhinitis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13188211

Enrollment

120

Registered

2022-09-01

Start date

2022-09-07

Completion date

Unknown

Last updated

2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment of patients with allergic rhinitis Respiratory

Interventions

This study is expected to include patients with allergic rhinitis. The patients will be sequentially assigned to two groups, one using nasal spray with licorice extract and the other using nasal spray

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with allergic rhinitis; the diagnostic criteria require a visual analogue scale (0-100) in the four categories of sneezing, itchy nose, rhinorrhea and nasal obstruction with a summed score greater than 120, and immunoglobulin E greater than 120 kU/L, and more than one inhalation allergen, such as dust.

Exclusion criteria

Exclusion criteria: 1. Patients aged less than 20 years 2. A history of allergy to licorice or corticosteroid 3. Pregnancy 4. A history of malignancies of the sinuses or nasopharynx 5. Patients who had undergone turbinate, septum or sinus surgery 6. If steroids or antihistamines is used in the month prior to inclusion, one month of cessation is required to conduct the trial.

Design outcomes

Primary

Measure	Time frame
The four main symptoms of allergic rhinitis (sneezing, itchy nose, rhinorrhea, and nasal obstruction) are evaluated using a visual analogue scale (0-100) before treatment, at two weeks and four weeks. In addition, SNOT-22 is also used to evaluate 22 allergic rhinitis-related symptoms in patients, and the scores are summed to compare the improvement of the total score before treatment and at two and four weeks.	—

Measure

Time frame

The four main symptoms of allergic rhinitis (sneezing, itchy nose, rhinorrhea, and nasal obstruction) are evaluated using a visual analogue scale (0-100) before treatment, at two weeks and four weeks. In addition, SNOT-22 is also used to evaluate 22 allergic rhinitis-related symptoms in patients, and the scores are summed to compare the improvement of the total score before treatment and at two and four weeks.

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Secondary

Measure	Time frame
We used acoustic rhinometry to assess the improvement in nasal resistance before and after treatment, record and compare the improvement of the inferior turbinate hypertrophy before and after treatment with endoscopy, and collect nasal secretions to investigate the changes of intranasal microenvironment before and after treatment were analyzed and compared. All three measurements are assessed before treatment and at two and four weeks of treatment.	—

Measure

Time frame

We used acoustic rhinometry to assess the improvement in nasal resistance before and after treatment, record and compare the improvement of the inferior turbinate hypertrophy before and after treatment with endoscopy, and collect nasal secretions to investigate the changes of intranasal microenvironment before and after treatment were analyzed and compared. All three measurements are assessed before treatment and at two and four weeks of treatment.

—

Countries

Taiwan

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 19, 2026