Metabolic syndrome, according to the National Cholesterol Education Program-Adult Treatment Panel III Nutritional, Metabolic, Endocrine Metabolic syndrome
Conditions
Interventions
The two phases of the crossover design included a carbohydrate-restricted Paleolithic-based diet with sedentary behavior (CRPD-Sed) and a carbohydrate-restricted Paleolithic-based diet with high inten
Sponsors
Grand Valley State University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-60 years 2. Metabolic syndrome (MetS), according to the National Cholesterol Education Program-Adult Treatment Panel III. 3. Stable weight for at least 3 months 4. Relatively sedentary (defined as engaged in exercise <30 min/day or VO2 peak <45 ml/kg/min)
Exclusion criteria
Exclusion criteria: 1. Special diets 2. Medications for chronic disease 3. Cardiovascular, metabolic, pulmonary, or osteoarticular disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular and metabolic health were assessed following 4 weeks of diet or diet and exercise intervention. Blood was collected at 0, 4, 8, and 12 weeks. Assessments included lipoprotein markers (Cholestech LDX® system), adiposity (hydrostatic weighing), metabolic markers (enzyme-linked immunosorbent assay) and VO2max (peak exercise test). | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognition functioning was assessed using Brain-Derived Neurotrophic Factor protein content (enzyme-linked immunosorbent assay), performance on the Stroop Test, as well as a self-reported measure of cognitive symptoms and function (Medical Outcomes Study Cognitive Functional Scale). | — |
Countries
United States of America
Outcome results
None listed