Parkinson's disease Nervous System Diseases
Conditions
Interventions
Participant recruitment:
People with Parkinson's Disease (PD) will be recruited from the Portuguese Parkinson Disease Association (APDPK) and from the Movement Disorders Outpatient Cli
b) Fear of falling (Falls Efficacy Scale - FES-I).
c) Clinical impairments (The Movement Disorder Society Unified Parkinson Disease Rating Scale - MDS-UPDRS)
d) Frequency and severity of falls (falls weekly registry)
e) Gait (Motor a
Sponsors
Fundação para a Ciência e Tecnologia
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of idiopathic Parkinson’s disease (Movement Disorder Society Parkinson’s Disease criteria) 2. Hoehn and Yahr stages II-IV 3. Age above 18 years 4. Able to walk independently and currently able to tolerate a minimum 1 hour of exercise 5. Able to communicate with the investigator, to understand and comply the study procedures 6. Willing and able to provide written informed consent to participate and understand the right to withdraw his/her consent at any time without prejudice to future medical care
Exclusion criteria
Exclusion criteria: 1. Severe postural instability assessed by MDS-UDPRS Part III item 3.12 2. Severe cognitive difficulties and significant active psychiatric problems that aggravate when exercising
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in the Balance Evaluation Systems Test (Mini-BEST Test) at baseline (T0) after 8 weeks training protocol (T1) and 3 months after the ending of the program (T2). 2. Change in the Falls Efficacy Scale (FES-I) at baseline (T0) after 8 weeks training protocol (T1) and 3 months after the ending of the program (T2). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical impairments measured using the Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UPDRS) at baseline (T0) after 8 weeks training protocol (T1) and 3 months after the ending of the program (T2). 2. Frequency and severity of falls measured using a falls weekly registry at T0, T1 and T2. 3. Gait measured using Motor and Cognitive Timed Up Go Test (TUG) at T0, T1 and T2. 4. Physical capacity measured using the 6 min walking distance test (6MWD) at T0, T1 and T2. 5. Cognition measured using the Montreal Cognitive Assessment (MoCA) at T0, T1 and T2. 6. Quality of life measured using the short version of Parkinson Disease Questionnaire (PDQ8) at T0, T1 and T2. 7. Nonlinear gait and balance analysis: For dynamic parameters, participants will walk on a treadmill for 10 min. Stride intervals will be determined from an accelerometer placed at their ankles. The static balance parameters will be tested in both eyes opened and closed conditions. They will be asked to remain quiet for 2 min. These two tests will be applied at T0, T1 and T2. | — |
Countries
Portugal
Outcome results
None listed