Predictive markers of gestational diabetes mellitus in first and early second trimester of pregnancy

Adiponectin, leptin, sex hormone-binding globulin (SHBG) and lipid profile values during the first or early second trimester of pregnancy and the subsequent risk of gestational diabetes mellitus later in pregnancy

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN13134709

Enrollment

150

Registered

2017-03-20

Start date

2017-04-01

Completion date

Unknown

Last updated

2018-11-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gestational diabetes mellitus Pregnancy and Childbirth Gestational diabetes mellitus

Interventions

At 11 - 13 (plus six days) weeks of pregnancy, blood samples from pregnant participants are collected and stored at -80 C. At 24 to 28 weeks of gestation, according to the results of the 2 hour 75 g

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Female 2. Age over 18 years 3. Singleton pregnancies

Exclusion criteria

Exclusion criteria: 1. Age under 18 years 2. Multiple pregnancy 3. Pre-existing type 1 or type 2 diabetes mellitus 4. Chronic hypertension 5. Preeclampsia, eclampsia 6. Hypothyroidism 7. Pre-existing renal or hepatic impairment 8. Other chronic diseases (e.g. valvular heart disease) 9. Vaginal bleeding (e.g. placental abruption) 10. Special diets (e.g. lactose intolerance) 11. Inadequate monitoring during pregnancy

Design outcomes

Primary

Measure	Time frame
1. Serum adiponectin is measured using blood samples at 11-13 (plus six days) weeks of pregnancy 2. Serum leptin measured using blood samples at 11-13 (plus six days) weeks of pregnancy	—

Secondary

Measure	Time frame
1. Serum sex hormone-binding globulin (SHBG) are measured using blood samples at 11-13 (plus six days) weeks of pregnancy 2. Lipid profile (total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol) are measured usng blood samples at 11-13 (plus six days) weeks of pregnancy 3. Atherogenic markers (LDL cholesterol, HDL cholesterol, triglycerides, HDL cholesterol and total cholesterol, HDL cholesterol) are measured using blood samples at 11-13 (plus six days) weeks of pregnancy	—

Measure

Time frame

1. Serum sex hormone-binding globulin (SHBG) are measured using blood samples at 11-13 (plus six days) weeks of pregnancy 2. Lipid profile (total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol) are measured usng blood samples at 11-13 (plus six days) weeks of pregnancy 3. Atherogenic markers (LDL cholesterol, HDL cholesterol, triglycerides, HDL cholesterol and total cholesterol, HDL cholesterol) are measured using blood samples at 11-13 (plus six days) weeks of pregnancy

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Countries

Greece

Contacts

Public ContactGeorgios Asimakopoulos

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026