Healthy volunteers and patient volunteers of all conditions Not Applicable
Conditions
Interventions
Participants have one or more of the following samples taken at a single visit: sputum, blood, urine, nasal, stool or skin.
Sponsors
Medicines Evaluation Unit
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Able to give written informed consent 2. Males and females aged over 18 years 3. Procedure specific criteria
Exclusion criteria
Exclusion criteria: 1. History of anaemia or identified by haemocue test at screening or other clinically significant haematological disorders for blood donation 2. Current acute illness 3. Pregnancy or breastfeeding 4. History of Hepatitis B/C or HIV infection or a positive test at screen if required by the specific project 5. Volunteers who have donated to the blood transfusion service in the past 4 months, if applicable (applicable for blood donation or if specified for other procedures as per project-specific exclusion criteria) 6. Suspected use of drugs of abuse or positive drug screen, if required 7. Any contraindications for nasal sampling e.g. history of epistaxis, nasal defects, as assessed by the physician 8. Procedure-specific criteria and contraindications for performing the specific procedure 9. Any reason that the physician deems the subject not suitable to undertake the procedure(s)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sputum eosinophil counts in stable state measured using cytology at a single timepoint | — |
Secondary
| Measure | Time frame |
|---|---|
| Sputum supernatant cytokines including IL-8 and TNF-a in stable state measured using immunoassay at a single timepoint | — |
Countries
England, United Kingdom
Contacts
Public ContactNatalie Jackson
Outcome results
None listed