Acute heart failure Circulatory System
Conditions
Interventions
Patients hospitalized for acute heart failure will be followed for 6 months. The trajectory of voice alteration will be tracked through daily voice recordings. Follow-ups will be conducted at 6 weeks
Sponsors
University Hospital Würrzburg
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Hospitalization for AHF (consecutive patients, Dept. of Internal Medicine I) 2. Age =18 years 3. Written informed consent 4. Willingness to attend planned follow-up visits at the Comprehensive Heart Failure Center (CHFC) 5. Life expectancy =6 months
Exclusion criteria
Exclusion criteria: 1. High output heart failure 2. Cardiogenic shock 3. High-urgency listing for heart transplant 4. Left ventricular assist device (LVAD) implanted/planned 5. History of vocal fold disorder or vocal fold surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of vocal biomarker during an acute heart failure episode at index hospitalization (Baseline), assessed through daily voice recordings | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in the vocal biomarker during the 6-month observation period, assessed through daily voice recordings. 2. Type and prevalence of vocal cord dysfunction assessed by video-stroboscopy during an AHF episode (Baseline), 6 weeks (F6w), 6 months (F6m) after hospitalization for AHF 3. Cardiac structure and function, assessed by echocardiography at Baseline, F6w, F6m 4. Heart failure severity (NYHA, NT-proBNP, 6-min walking distance) at Baseline, F6w, F6m 5. Pulmonary function assessed by pulmonary function tests at F6w, F6m 6. Quality of life assessed by questionnaires at Baseline, F6w, and F6m 7. (Re-)Hospitalization (for worsening HF and all-cause, respectively) at F6w and F6m, taken from medical records 8. Death (cardiac and all-cause, respectively) at F6w and F6m, taken from medical records | — |
Countries
Germany
Contacts
Public ContactFabian Kerwagen
Outcome results
None listed