Borderline personality disorder Mental and Behavioural Disorders
Conditions
Interventions
Visit 1 - Screening visit (in person, ~2-3 hours):
Participants will be invited to the NIHR Oxford Health Clinical Research Facility (CRF) at the Warneford Hospital in Oxford for their baseline screen
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1.Participants belonging to one of the following groups: 1.1. Individuals with a confirmed diagnosis of borderline personality disorder 1.2. Individuals with no psychiatric diagnosis (healthy control group only) 2. Aged 18-35 years 3. Of any gender 4. Willing and able to give informed consent 5. Sufficient grasp of the English language to permit meaningful explanation of study procedures and cognitive testing 6. Willing and able to engage with study procedures 7. Access to WiFi at home
Exclusion criteria
Exclusion criteria: 1. Admission to a psychiatric hospital or contact with crisis services in the 2 months prior to study entry 2. Past confirmed diagnosis of psychosis, schizophrenia or bipolar disorder 3. No past diagnosis of borderline personality disorder (healthy control group only) 4. Judged to be at significant immediate risk of suicide/self-harm 5. Clinically significant drug or alcohol misuse 6. Regular use of benzodiazepine or hypnotic drugs 7. Any other medications or health conditions which may significantly impact the data collected (e.g. epilepsy, past traumatic brain injury, high dose steroids) 8. Current participation in a research study involving an investigational medicinal product 9. Employed in shift work that may require changes to sleeping/activity patterns outside of a participant's usual routine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Engagement with the Cumulus platform quantitively measured by the number of EEG test sessions completed on the Cumulus platform over the 7-week study period and qualitatively assessed via themes emerging from the post-study semistructured interviews 2. Engagement with the actigraphy watch quantitively measured by the total recorded actigraphy watch wear time over the 7-week study period and qualitatively assessed via themes emerging from the post-study semi-structured interviews 3. Engagement with online mood questionnaires quantitively measured by the number of mood prompts responded to over the 7-week study period and qualitatively assessed via themes emerging from the post-study semistructured interviews | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Mood instability measured using time-adjusted root mean square of successive differences (RMSSD) in self-reported mood measures across the 7-week study period 2. Cognitive Function measured using mean performance indicators, and change over time, on the Digit Symbol Substitution test (DSST) and Flanker error-related negativity (FERN) task completed multiple times per week over the 7-week study period 3. Brain activity summary measures recorded using portable EEG multiple times per week over the 7-week study period | — |
Countries
England, United Kingdom
Contacts
Public ContactKate Saunders
Outcome results
None listed