Parkinson's disease Nervous System Diseases Parkinson disease
Conditions
Interventions
Potential participants from the Hospital's Parkinson's disease clinic were asked if they would be able to regularly attend three high-intensity exercise sessions of the described characteristics, incl
Sponsors
Fundación Santa Fe de Bogotá
Universidad del Rosario
Universidad de los Andes
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Idiopathic PD confirmed by a movement disorder specialist 2. Hoehn & Yahr stage 1 to 3 3. Age 65 or younger 4. Stable dopaminergic therapy 5. A negative exercise stress test
Exclusion criteria
Exclusion criteria: 1. Surgery for Parkinson's disease 2. Cancer 3. Musculoskeletal diseases 4. Coronary disease 5. Hyperthyroidism 6. COPD 7. Severe visual problems 8. History of stroke 9. Anemia 10. Use of anticoagulants 11. Use of a pacemaker 12. Use of an insulin pump 13. Mini-mental score below 24
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease severity, assessed using the Unified Parkinson's Disease Rating Score (UPDRS) before and right at the end of the 16-week intervention period | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured before and right at the end of the 16-week intervention period: 1. Maximal oxygen consumption (VO2 max) 2. Body composition measures: BMI, % body fat, % lean mass, abdominal circumference 3. Cortical activations in functional Magnetic Resonance Imaging (fMRI) 4. Plasma concentrations of Parkinson's disease biomarkers: BDNF, PGDF-BB, Cathepsin-D, NGF, RANTES, ICAM-1 | — |
Countries
Colombia
Outcome results
None listed