Use of non-invasive mechanical ventilation with pressure support guaranteed with average volume (AVAPS) in de novo hypoxemic respiratory failure

AVAPS in de novo hypoxemic respiratory failure

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN13036391

Enrollment

Registered

2017-07-26

Start date

2010-12-01

Completion date

Unknown

Last updated

2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

De novo hypoxemic respiratory failure (not produced by acute exacerbations of COPD, chronic pulmonary diseases or congestive heart failure) Respiratory

Interventions

The study consists of subjecting patients to noninvasive ventilation using a new strategy that includes the programming of ventilatory parameters in BiPAP S / T AVAPS mode in order to observe if this

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years and over 2. Patients who presented with signs of acute respiratory failure at the emergency room (RR >25 breath for minute, use of accessory muscles) for de novo hypoxemic respiratory failure (not produced by acute exacerbations of COPD, chronic pulmonary disease or congestive heart failure) with PaO2/FIO2 of mild to moderate as per thresholds defined in the Berlin criteria for the ARDS

Exclusion criteria

Exclusion criteria: 1. Facial deformity 2. Obstruction of the upper airway by surgery or trauma 3. Alterations in the central nervous system does not relating to hypercapnic encephalopathy 4. Cardiogenic pulmonary edema, pulmonary embolism, pneumothorax, hemoptysis, or septic shock 4. Urgent intubation due to cardiorespiratory arrest and hemodynamic instability with systolic pressure less than 80 mmHg 5. Hemodynamic instability 6. Excess of respiratory secretions 7. Non-cooperative or agitated 8. Unable to use the interface device 9. Recent surgery of the upper airway 10. Received NIV with “DO NOT RESUSCITATE ORDERS"

Design outcomes

Primary

Measure	Time frame
Success or failure of the use of the NIV (expressed as percentage), evaluated during stay in ICU and follow-up until discharge from hospital	—

Secondary

Measure	Time frame
Evaluated during stay in ICU and follow-up until discharge from hospital: 1. Days of hospitalization (expressed in days) 2. Proportion requiring endotracheal intubation (expressed as percentage) 3. Death (expressed as percentage of patients)	—

Countries

Ecuador

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026