Aortic stenosis and acute coronary syndrome Circulatory System
Conditions
Interventions
Patients meeting the inclusion criteria will be approached for informed, written consent for the abbreviated research scan prior to their standard scan appointment. If they decline participation in th
Sponsors
University Hospitals of Leicester NHS Trust
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Aortic stenosis cohort: 1. Provision of written informed consent 2. Known aortic stenosis of any degree 3. Must have had a prior baseline minimum standard echocardiogram dataset (BSE) at least 6 months ago 4. Outpatient or inpatient Acute coronary syndrome: 1. Provision of written informed consent 2. Inpatient admitted with ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI) or unstable angina defined by two or more of raised cardiac troponin, ECG changes and/or symptoms as per European Society of Cardiology definitions 3. Outpatient if post-discharge without having an IP transthoracic echocardiogram (TTE) 4. Include MI with non-obstructive coronary artery (MINOCA) 5. Pre- and post-angiography patients will be included 6. Patients deemed to have Takotsubo cardiomyopathy will also be included
Exclusion criteria
Exclusion criteria: Aortic stenosis: 1. Unwilling or unable to provide written consent 2. Patient with other significant pathology on baseline echo which needs re-assessment (other valve disease, cardiomyopathies, etc) 3. Patient with poor echo views 4. Adult congenital heart disease (exception of bicuspid aortic valve) Acute coronary syndrome cohort: 1. Unwilling or unable to provide written consent 2. Heart failure as primary diagnosis 3. Patients with known at least moderate severity of valve disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety measured using the severity of disease as assessed in the report of the abbreviated protocol against the full report as gold standard. The number of missed other pathologies will also be assessed. Overall agreement, sensitivity and specificity of the abbreviated protocols will be measured statistically. All data will be measured at a single timepoint after the recruitment and once all data has been collected. | — |
Countries
England, United Kingdom
Contacts
Public ContactPooja Raithatha
Outcome results
None listed