Schizophrenia, bipolar disorder Mental and Behavioural Disorders
Conditions
Interventions
This is a prospective, observational, longitudinal de novo multicenter cohort study conducted across nine CIBERSAM research groups in eight Spanish National Health System centres in four autonomous co
2. Fasting peripheral blood sampling for: inflammatory cytokines (IL-6, IL-10, TNF-a) by multiplex xMAP/Luminex
neurotrophins (BDNF, NT-3) by ELISA
leukocyte-endothelial interaction in dynamic parallel-flow chamber
mitochondrial function and oxidative stress by fluorimetric techniques
and full metabolic profile (HbA1c, fasting glucose and insulin [HOMA index], lipid profile, microalbuminuria, hsCRP).
3. Physical frailty assessment using the Fried phenotype (unintentional weight los
supplemented by the 5-repetition Sit-to-Stand te
Sponsors
Centro de Investigación Biomédica en Red de Salud Mental
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Adults aged =18 years 2. Confirmed diagnosis of schizophrenia or bipolar disorder according to DSM-5-TR/ICD-11 (patient groups) 3. Unaffected first-degree relatives (parents, siblings or offspring) of individuals with schizophrenia or bipolar disorder (relative groups) 4. No personal or first-degree family history of mental disorder (healthy control group) 5. Written informed consent provided
Exclusion criteria
Exclusion criteria: 1. Major neurocognitive disorder or intellectual disability 2. Sensory or language barriers precluding cognitive assessment 3. For relative and healthy control groups: any lifetime diagnosis of a psychotic or major affective disorder
Countries
Spain
Contacts
Public ContactPatricia;Rafael Correa-Ghisays;Tabarés-Seisdedos
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Outcome results
None listed