Acute respiratory infections Respiratory Acute upper respiratory infections
Conditions
Interventions
In the intervention group, results of real-time PCR were communicated to the clinician within 48 hours. In the control group the same was provided, but after 4 weeks. Follow up time ended at discharge
Sponsors
Reinier de Graaf Hospital (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Children under age of 2 months with a respiratory tract infection 2. Children older than 2 months with a respiratory tract infection and severe respiratory problems with tachypnoea, dyspnoea or cyanosis 3. Gender: both male and female
Exclusion criteria
Exclusion criteria: Aged older than 12 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in clinical decision making: 1. Hospital admission yes or no: measured at first clinical presentation 2. Duration of hospital stay in days: measured after discharge at hospital 3. Start of antibiotics yes or no: measured at any time from first presentation until discharge 4. Duration of antibiotic use in days when initiated: measured after discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| Epidemiology of respiratory tract infections in children; all measured at any time from first presentation until discharge: 1. Clinical symptoms and disease severity of new viral pathogens; are there differences between the pathogens? 2. Clinical symptoms and disease severity of multiple infections; differences with monoinfections 3. Relation between viruses and laboratory parameters (C-reactive protein [CRP] for example) 4. What is the role of Bordetella pertussis in children with acute respiratory infection and should it be tested routinely 5. Cost changes as a result of introduction of PCR diagnostics | — |
Countries
Netherlands
Outcome results
None listed