Perspective of different forms of essential amino acid supplements and effects on appetite in older men and women

The impact of essential amino acid supplements enriched with L-leucine on appetite and energy intake in elderly: a randomised, crossover trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12977929

Enrollment

Registered

2016-07-01

Start date

2015-07-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional supplements Nutritional, Metabolic, Endocrine

Interventions

There are two arms to the study. Each participant can choose whether to take part in both arms or just one. If they choose to take part in one arm, they can also decide which arm they wish to take par

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male and female adults aged between 60 and 80 2. Free from vascular and metabolic disease

Exclusion criteria

Exclusion criteria: 1. Smoking 2. Use of oestrogens within the previous three months 3. Lactose intolerant

Design outcomes

Primary

Measure	Time frame
Arm 1: 1. Composite appetite ratings using visual analogue scales, taken at baseline immediately post-consumption and every 15 min until post consumption of the ad lib breakfast 2. Energy intake, measured via the quantity of breakfast consumed Arm 2: Composite appetite ratings using visual analogue scales before and after the ad lib breakfast	—

Secondary

Measure	Time frame
Arm 1: 1. Gut hormone concentrations from blood samples, via plate reader and ELISA. Measurements to be taken at baseline immediately post-consumption and every 30 min until the ad lib breakfast 2. Plasma concentration of essential amino acids from blood samples, via gas chromatography mass spectrometry. Measurements to be taken at baseline immediately post-consumption and every 30 min until the ad lib breakfast 3. Palatability, measured using visual analogue scales. Measurements to be taken at baseline immediately post-consumption and every 15 min until post consumption of the ad lib breakfast Arm 2: Palatability, measured using visual analogue scales before and after the ad lib breakfast	—

Measure

Time frame

Arm 1: 1. Gut hormone concentrations from blood samples, via plate reader and ELISA. Measurements to be taken at baseline immediately post-consumption and every 30 min until the ad lib breakfast 2. Plasma concentration of essential amino acids from blood samples, via gas chromatography mass spectrometry. Measurements to be taken at baseline immediately post-consumption and every 30 min until the ad lib breakfast 3. Palatability, measured using visual analogue scales. Measurements to be taken at baseline immediately post-consumption and every 15 min until post consumption of the ad lib breakfast Arm 2: Palatability, measured using visual analogue scales before and after the ad lib breakfast

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Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 8, 2026