Distractibility in attention deficit hyperactivity disorder Mental and Behavioural Disorders
Conditions
Interventions
This is a single-centre, interventional, double-blinded, randomised controlled trial with a 2 (group: High ASRS vs Low ASRS) x2 (Intervention vs placebo) x2 (pre and 90 minutes post) design, and a 1:1
thus, they were concealed from the investigator with the use of sealed envelopes.
Participants in the intervention group are given an acute 200mg dose of 5-hydroxytryptophan, provided by 2 tablets of
Sponsors
University of Sheffield
Eligibility
Sex/Gender
All
Age
18 Years to 65 Months
Inclusion criteria
Inclusion criteria: 1. For control participants, a score of 1 or less on the Adult ADHD self-report screener (ASRS v1.1, items 1-6) 2. For high ASRS participants, a score of 4 or greater on the Adult ADHD self-report screener (ASRS v1.1, items 1-6) 3. Normal or corrected-to-normal vision
Exclusion criteria
Exclusion criteria: 1. Users of psychostimulant medication 2. Users of serotonin-affecting medication, e.g., SSRIs 3. Smokers/Vapers 4. Pregnant and breastfeeding people 5. Lactose-intolerant people 6. Vegans 7. Dyslexia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Distractibility, measured using reaction time and accuracy in a task-relevant and task-irrelevant distractor task, before administration and at 90 minutes post administration | — |
Secondary
| Measure | Time frame |
|---|---|
| The prevalence of ADHD symptom types was measured using the extended ADHD self-report scale (ASRS) v1.1 questionnaire during the pre-screening of participants | — |
Countries
England, United Kingdom
Contacts
Public ContactEleanor Jackson
Outcome results
None listed