Improve motor cortical excitability and balance dysfunction to provide practical guidance for the task-related brain state (TCBS) treatment of movement-related diseases, such as stroke Nervous System Diseases
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Criteria specified in the TMS safety guidelines 2. Right-handed hand 3. Age range: 20-75 years old 4. No metal implants on the head 5. Healthy, No neurological or psychiatric disorders 6. No severe visceral diseases such as liver, lung, heart, kidney, etc 7. Voluntarily participate and sign an informed consent form 8. No severe motor function and able to complete exercise tests 9. Not receiving any drug treatment
Exclusion criteria
Exclusion criteria: 1. A history of neurological or psychiatric disorders 2. Receiving any drug treatment 3. Unwilling to have TMS 4. Unwilling to record EEG 5. Contraindications to magnetic stimulation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following primary outcome measures were assessed using electromyography before intervention (TASK), 5 min after intervention (TASK5), and 20 min after intervention (TASK 20): 1. Reaction time, characterized between the ‘0’ cue and feedback 2. Movement performance, defined as the percentage of the sum of OK and GOOD among total trials | — |
Secondary
| Measure | Time frame |
|---|---|
| Motor cortical excitability measured using electroencephalography (EEG) during a resting state with eye open (pre-REST), 0 min after intervention (POST0) and with a resting state 25 min after intervention (post-REST) | — |
Countries
China