Severe acute pancreatitis Digestive System Acute pancreatitis
Conditions
Interventions
Group one: Enteral nutrition via nasogastric/nasojejunal tube, or sip feed, composition as stratified for each centre. To start immediately after randomisation.
Group two: ?Standard? fluid replacemen
Sponsors
Barts and the London NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged 18 or over with a proven diagnosis of acute pancreatitis (pain and raised enzymes or computed tomography [CT] evidence) together with systemic inflammatory response syndrome (SIRS) or organ failure (Marshall score 2 or more for any organ system except liver, or Atlanta criteria) present for 24 hours or more, and within 72 hours of onset of symptoms.
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of proportion of patients with increased gut permeatbility from 80% by half to 40%. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Reduction in persistent organ failure (3 days) from 35% to 15% 2. Complications (with specific emphasis on infective complications). 3. Length of hospital/ICU stay 4. Return of normal GI function 5. Markers of intestinal ischaemia (Intestinal fatty acid binding protein) and other markers of gut permeability (endocAb), immune/inflammatory response | — |
Countries
United Kingdom
Outcome results
None listed