Contamination with toxic material Injury, Occupational Diseases, Poisoning
Conditions
Interventions
All participants will be dosed with a fluorescent chemical contaminant over a total of 16 discrete areas of clothing, hair and skin. They are randomly assigned to two groups using an online treatment
10 mg mL-1) dissolved in methyl salicylate (‘CMX’). This will be applied to each volunteer as a 10 µL droplet (hair and skin surfaces) or as a 100 µL droplet (over clothing). The total dose of methyl
Sponsors
Intertox Ltd
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Volunteers 2. Male or female 3. Age 18 – 60 (at the start of the study)
Exclusion criteria
Exclusion criteria: 1. Allergy to aspirin 2. Renal impairment 3. Inflammatory disorder affecting the skin 4. Partially healed/open wounds 5. Respiratory condition (other than controlled asthma) 6. Pregnant or breastfeeding 7. Any other relevant condition at the discretion of an independent physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effectiveness of the protocol, determined by LC-DAD-MS measurements of the amount of a chemical contaminant (curcumin/methyl salicylate mixture) recovered from the hair and skin of exposed participants in comparison with a control (exposed, untreated) treatment group | — |
Secondary
| Measure | Time frame |
|---|---|
| The distribution of the chemical mixture on hair and skin surfaces, observed by fluorescent imaging of exposed participants in comparison with a control (exposed, untreated) treatment group | — |
Countries
United Kingdom
Contacts
Public ContactTracey Thomas
Outcome results
None listed