Newborn with a collodion membrane or congenital erythroderma or erythroderma developed in the first four weeks after birth. Skin and Connective Tissue Diseases
Conditions
Interventions
A national multidisciplinary protocol with a diagnostic flowchart will be used. Basic diagnostics include basic laboratory investigations, a skin biopsy and 2x3 ml blood for genetic tests. The genetic
Sponsors
Erasmus Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Collodion membrane at birth or 2. Erythroderma at birth or 3. Erythroderma developed in neonatal period (first four weeks postpartum)
Exclusion criteria
Exclusion criteria: Erythroderma developed after the first month postpartum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical characteristics, observed by the clinician, such as erythroderma, collodion membrane, bullae, alopecia etc. These will be measured during first clinical visit. Histological data (skin biopsy) and laboratory findings (normal blood count, total IgE, etc) will be collected. The data for these findings can be different per individual, because not every child/neonate will be seen by a clinician at the same time (e.g. day 1, week 1, etc.). | — |
Secondary
| Measure | Time frame |
|---|---|
| Morbidity and mortality | — |
Countries
Netherlands
Outcome results
None listed