A deep infrabony defect = 4 mm deep caused by periodontal disease Oral Health
Conditions
Interventions
All patients will be enrolled in a strict nonsurgical periodontal program that included systemic antibiotic therapy, careful instructions on proper oral hygiene measures and subgingival scaling and ro
Sponsors
National Autonomous University of Mexico [UNAM] (Mexico)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients 45 to 64 years old 2. Have atraumatic occlusion but vertical bone defect maximum two walls affected and loss of adhesión 3. = 4 mm deep, controlled chronic degenerative disease 4. Good nutritional status 5. Manually skilled and ability to follow instructions 6. Able to give informed consent
Exclusion criteria
Exclusion criteria: 1. Smoking 2. People who have taken antioxidant supplements or anti-inflammatories in the last 6 months 3. Family history of osteoporosis 4. Family history of cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Probing depth, gingival recession, and attachment loss via clinical assessments at post-surgery follow-up (3, 6 and 12 months after Phase 1) 2. Evolution of periodontal disease and bone regeneration via Cone-Beam Computed Tomography, radiography and intraoral photographs at post-surgery follow-up (3, 6 and 12 months after Phase 1) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Concentration of oxidative stress and chronic inflammatory markers by TBARS assay, Total Antioxidant Status, superoxide dismutase activity and quantification of cytokines at post-surgery follow-up (3, 6 and 12 months after Phase 1) 2. Regeneration of bone tissue, via changes in bone density via Cone-Beam Computed Tomography at 3, 6 and 12 months after Phase 1 3. Mobility of teeth, tested clinically by a specialist at 3, 6 and 12 months after Phase 1 | — |
Countries
Mexico
Outcome results
None listed