Post-traumatic stress disorder (PTSD), depression, anxiety disorder, prolonged grief. At least one of these conditions must be present at study intake, either at syndromal (DSM-5 diagnoses) or subsyndromal level. Mental and Behavioural Disorders
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Being a Holocaust survivor, i.e., born 1945 or earlier in Europe and having experienced persecution, concentration camp, witnessing torture or death, or having to survive in hiding and/or other traumatic events by the Nazi regime during World War II. 2. Diagnosis of one or more of the following conditions: PTSD, complex PTSD, depressive disorder (Major, minor depression), anxiety disorder, prolonged grief disorder. Patients with a subsyndromal form of the mentioned disorders can also be admitted to the study. 3. Participants do not receive any psychotherapy treatment during the time of the study (except for LRT in the intervention condition). 4. Participants must have been informed about the study and must have given written informed consent. This includes that he/she is willing to be randomized to one of the study conditions.
Exclusion criteria
Exclusion criteria: 1. Probable dementia (MMSE < 26), 2. Acute psychotic disorder 3. Acute suicidality
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoints are PTSD and depressive symptoms, assessed at baseline, end of treatment, follow-up at 6 months: 1. PTSD symptoms assessed using PTSD Checklist for DSM-5 (PCL-5) 2. Depressive symptoms assessed using Patient Health Questionnaire (PHQ-9) and Geriatric Depression Scale (GDS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are assessed at baseline, end of treatment, follow-up at 6 months: 1. Other symptom measures - Complex PTSD symptoms: The complex PTSD part of the ICD-11 Trauma Questionnaire - Anxiety symptoms: The Depression Anxiety Stress Scale-21 (DASS-21) - Grief symptoms: The ICD-11 Symptom-Diagnostic Test for Prolonged Grief Disorder (PG-ICD-11) 2. Process measures - Dysfunctional thoughts: The Posttraumatic Cognitions Inventory (PTCI) - Reminiscence style: The Reminiscence Functions Scale (RFS) - Positive well-being: The Life Satisfaction Index (LSI) - Posttraumatic growth: The Posttraumatic Growth Inventory (PTGI) 3.Furthermore, sociodemographic characteristics (age, gender, educational level) and cognitive status (Mini Mental Status Examination, MMSE) are assessed at baseline. | — |
Countries
Israel