Dementia Mental and Behavioural Disorders
Conditions
Interventions
170 participants from the cognitive disorders clinic at the National Hospital for Neurology and Neurosurgery (UCLH) will be recruited. These participants are due to have a same-day MRI scan which take
Sponsors
University of London
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. An individual with ability to engage in the decision to participate in the research study and provide informed consent 2. Aged 18 years old and above Main study: Patients attending the CDC at NHNN and at Darent Valley Hospital who are due to have a standard-of-care MRI of the brain as part of their routine investigation. Sub-study 1: Participants in other REC approved studies, who are scheduled for a planned MRI brain scan Sub-study 2: Healthy controls recruited through spouses/partners of patients, individuals who are included on the DRC Research Register and Join Dementia Research and patients attending the CDC at NHNN and at Darent Valley Hospital Sub-study 3: Participants recruited to the main study who are happy to be contacted about follow-up study procedures
Exclusion criteria
Exclusion criteria: 1. Unable to tolerate a routine MRI scan plus a 7-minute fast-MRI scan 2. Unable to tolerate draw blood by venepuncture
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Non-inferiority of ultra-fast MRI compared to gold standard MRI assessed using a 5-point Likert scale at baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Stability of ultra-fast MRI compared to gold standard MRI, assessed using a 5-point Likert scale at 2 weeks to 2 months 2. Ability of ultra-fast MRI to track longitudinal change compared to gold standard MRI, assessed using a 5-point Likert scale at 1 year 3. Blood biomarkers assessed by immunoassays at baseline, 2 weeks to 2-month interval and 1-year interval | — |
Countries
England, United Kingdom
Contacts
Public ContactMillie Beament
Outcome results
None listed