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Risk study of pre-neoplastic lesions in the low esophagus

Risk study of pre-neoplastic lesions in differently-sized mucosa projections of columnar epithelium in the low esophagus

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
ISRCTN
Registry ID
ISRCTN12753474
Enrollment
1000
Registered
2019-02-13
Start date
2015-06-01
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Progression of Barrett's esophagus to adenocarcinoma Cancer Barrett oesophagus

Interventions

All consecutive patients coming in with a request for upper gastrointestinal endoscopy were included, regardless of the clinical indication, between April/2015 and August/2016. In per
the projection was measured and then biopsies were performed following the Seattle Protocol (Figs. 3, 4, 5, 6 and 7). The observation time was during the exam. There was no follow-up.

Sponsors

Hospital Universitário de Santa Maria
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Request for upper gastrointestinal endoscopy

Exclusion criteria

Exclusion criteria: 1. Oesophageal obstruction 2. Post-oesophagectomy and bariatric surgery patients 3. Projections =3cm 4. Patients under 18 years of age

Design outcomes

Primary

MeasureTime frame
Diagnosis of Barrett's esophagus was determined using upper gastrointestinal endoscopy to detect the presence of columnar mucosa in the esophagus in the shape of digitiform projections, or segments that cover the circumference of the esophagus partially or totally.

Secondary

MeasureTime frame
1. The number of suspected lesions was determined using upper gastrointestinal endoscopy. 2. The size of suspected lesions was measured using previously laser-graded biopsy clamp with 0.5cm intervals, designed by the author, and divided in three groups of interes: Group 1 - projections up to 0.99cm, group 2 - 1.00 to 1.99cm and group 3 - 2.00 to 2.99cm, and then biopsied following the Seattle Protocol. 3. The number of suspected lesions during endoscopic examination was 81, where 59 subjects (72.8%) did not confirm for Barrett's esophagus after histologic exam, and 22 (27.2%) were confirmed, representing 1.74% of sample total

Countries

Brazil

Contacts

Public ContactHairton Copetti

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026