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Antioxidants in the risk of cardiovascular disease

An observational cross-sectional cohort study of the protective role of antioxidants against oxidative stress and inflammation in patients with a risk of cardiovascular disease

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN12745004
Enrollment
140
Registered
2009-11-19
Start date
2008-09-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease Circulatory System Chronic ischaemic heart disease

Interventions

Patients diagnosed with non-acute coronary angiography for chest pain will be entered into the study in one of two groups: Group 1: significant stenosis of coronary arteries Group 2: patients without

Sponsors

Regional Hospital of Pardubice (Czech Republic)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Participants were recruited from the Department of Cardiology, Regional Hospital of Pardubice. Group 1: 1.1. Both males and females, aged 45 - 69 years 1.2. Patients with non-acute chest pain 1.3. Significant stenosis (coronary angiography) Group 2: 2.1. Both males and females, aged 45 - 69 years 2.2. Patients with non-acute chest pain 2.3. No stenosis (coronary angiography)

Exclusion criteria

Exclusion criteria: 1. Renal, hepatic or oncologic disease 2. Intake of vitamin and nutrition supplements

Design outcomes

Primary

MeasureTime frame
Measured from standard venous blood collection (see interventions section): 1. Beta-carotene 2. Alpha-tocopherol 3. Malondialdehyde 4. Free radicals 5. High sensitivity c-reactive protein (hsCRP) 6. Interleukin-6 (IL-6)

Secondary

MeasureTime frame
Measured from standard venous blood collection (see interventions section): 1. High density lipoprotein (HDL)-cholesterol 2. Low density lipoprotein (LDL)-cholesterol 3. Triglycerides 4. Total cholesterol 5. Glucose 6. Fibrinogen 7. Ceruloplasmin 8. Albumin 9. Transferrin 10. Haemoglobin

Countries

Czech Republic

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026