Systemic acute inflammatory response after wisdom tooth removal in otherwise healthy patients Oral Health Systemic Inflammatory Response Syndrome of non-infectious origin without organ failure
Conditions
Interventions
The test group will undergo third molar removal plus the application of Advanced Platelet-Rich Fibrin (A-PRF) on the alveolar socket.
The control group will receive the same procedure
Sponsors
University of Santiago de Compostela
Instituto Superior de Ciências da Saúde Egas Moniz
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Two unilateral fully impacted mandibular third molars which have the same degree of surgical difficulty comparing one side with the other 2. Healthy patients without significant medical diseases or a history of bleeding problems 3. Adequate level of plaque control (plaque index (PI) <15%) 4. Non-smokers patients 5. Able to give written consent
Exclusion criteria
Exclusion criteria: 1. Younger than 18 years old or older than 65 years old 2. Females who were pregnant or lactating 3. Females using contraceptive methods 4. Had any reported systemic illness 5. Had chronic use of any medication within 30 d prior to the study inclusion 6. Affected by periodontitis (Tonetti, Greenwell, & Kornman, 2018) 7. Signs of pericoronitis 8. Removable upper and/or lower partial dentures 9. Had periapical and periradicular radiolucencies that were detected on X-rays
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute inflammatory response measured by hs-C-reactive protein serum levels at 24 h after intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
Portugal
Outcome results
None listed