Does i-PRF (injectable platelet-rich fibrin) improve the quality of periodontal tissue and accelerate orthodontic tooth movement?

Effect of repeated injection of platelet-rich fibrin on crowded mandibular incisor alignment efficiency: a randomized controlled clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12737239

Enrollment

Registered

2024-04-15

Start date

2023-08-01

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malocclusion, Angle Class I

Interventions

Patients will be randomly allocated into two groups using Microsoft® Excel electronic randomization: Arm 1: Experimental group 1: I-prf will injected in the buccal sulcus of the mandibular incisors 1

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult patients. 2. Class I malocclusion with moderate crowding (4-6) mm. 3. Good oral hygiene and periodontal health. 4. No severe skeletal discrepancy. 5. Normal or inclination for the upper and lower incisors. 6. No congenitally missing or extracted teeth (except for the third molars).

Exclusion criteria

Exclusion criteria: 1. Patients with syndromes or craniofacial abnormalities. 2. Patients with vertical growth patterns. 3. Poor oral hygiene. 4. Previous orthodontic treatment.

Design outcomes

Primary

Measure	Time frame
Dentoalveolar changes before and after treatment will be assessed using cone-beam computed tomography: 1. Dentoalveolar changes including: 1.1. Dehiscence in the buccal alveolar bone. 1.2. Fenestration in the buccal alveolar bone. 1.3. Height and thickness of alveolar bone. 2. Keratinized tissue width. 3. Lower arch alignment time.	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Syria

Contacts

Public ContactMohammad Idris

mohammad.idris@damascusuniversity.edu.sy+963 964366915

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026