Effects of tracheotomy high-flow oxygen therapy on respiratory physiology

The relationship between the changes of the end-tidal lung volume and the work of the diaphragmatic muscle and the related respiratory muscles during tracheotomy high-flow oxygen therapy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12631125

Enrollment

Registered

2019-10-10

Start date

2019-10-17

Completion date

Unknown

Last updated

2020-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients aged 18 to 70 years old who were successfully detached from the ventilator after tracheotomy in the emergency care unit of Sir Run Run Shaw Hospital Respiratory

Interventions

Patients were kept in semi-recumbent position (the bed is tilted 30-45 degrees high), and the EIT belt is used to wrap the fifth or sixth intercostal space of the patient's chest, marking the upper an

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 70 years old 2. Patients who successfully detached from the ventilator for 24 years 3. Patients with mild to moderate respiratory distress syndrome and/or hypoxemia 4. Stable vital signs

Exclusion criteria

Exclusion criteria: 1. Hemodynamic instability (hypotension with mean arterial pressure of <60 mmHg despite volume loads or vasoactive drugs 2. Evidence of pneumothorax on chest X-ray or computed tomography scan 3. Respiratory failure explained by cardiac failure or fluid overload 4. Severe chronic obstructive pulmonary disease 5. Contraindication to electrical impedance tomography (EIT) (e.g. patients with implantable defibrillator, ETI belt positioning with wound dressing or chest drainage tube, etc)

Design outcomes

Primary

Measure	Time frame
Measured at the completion of each treatment with different oxygen supply modes at 30 minutes: 1. End-tidal lung volume measured using electrical impedance tomography (ETI) 2. Thickness of diaphragmatic muscle and the related respiratory muscle measured by ultrasound	—

Secondary

Measure	Time frame
Measured at the completion of each treatment with different oxygen supply modes at 30 minutes: 1. Respiratory rate, heart rate, blood pressure measured using patient monitor (Philips; mode: M8005A) 2. PECO2 measured by the end-of-breath carbon dioxide monitor (mode: M19042000) 3. Arterial blood gas measured by the Automatic blood gas, electrolyte and biochemical analyzer (mode: M18790600)	—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026