Chronic idiopathic cough Respiratory Chronic idiopathic cough
Conditions
Interventions
Subjects wear both an ambulatory cough monitor and a Holter ECG monitor which will record simultaneously for 24 hours.
Sponsors
University Hospital of South Manchester
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects who completed COMPASS Phase I and gave permission to be contacted by the research team regarding phase 2 2. Over 18 years of age 3. Cough subject only: Chronic cough, defined as a cough lasting longer than 8 weeks despite investigation and/or treatment trials for cough variant asthma, post-nasal drip and gastro-oesophageal reflux disease 4. No significant respiratory diseases (except chronic cough in the patient group)
Exclusion criteria
Exclusion criteria: 1. Recent upper respiratory tract infection (within 4 weeks) 2. Asthma; diabetic neuropathy; ischemic heart disease; fibromyalgia; previous brain injury; history of myocardial infarction or any other disorder deemed unsuitable by the investigator 3. Any neurological impairment which may have an effect on autonomic function and is deemed unsuitable by the investigator 4. Currently receiving ACE inhibitor treatment (e.g. lisinopril, perindopril, ramipril) 5. Currently on opiate cough suppressant treatment (e.g. codeine, morphine) 6. Current smoker or ex-smoker > 10 pack years still smoking within 6 months of study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate variability (HRV), calculated using the full 24 hour ECG trace recorded from the from the Holter device. A fast Fourier transform (FFT) method is used to investigate the changes in heart rate over the full day, to indicate autonomic activity. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cough count over 24 hours, recorded by the ambulatory cough monitor 2. Association between autonomic symptom score (COMPASS 31 questionnaire from part 1 of the study) and with cough counts and heart rate variability (HRV) | — |
Countries
England, United Kingdom
Contacts
Public ContactRachel Dockry
Outcome results
None listed