Therapy individualisation for patients with acute respiratory distress syndrome according to blood flow

Transpulmonary thermodilution before and during veno-venous extra-corporeal membrane oxygenation: an observational study on a potential loss of indicator into the extra-corporeal circuit

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN12607675

Enrollment

Registered

2018-08-15

Start date

2012-01-01

Completion date

Unknown

Last updated

2018-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress syndrome (ARDS) Respiratory Acute respiratory distress syndrome (ARDS)

Interventions

Participants were indicated for hemodynamic monitoring (transpulmonary thermodilution (TPTD)) and extracorporeal membrane oxygenation (ECMO) with very severe acute respiratory distress syndrome (ARDS)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 or older 2. Critically ill 3. Severe acute respiratory distress syndrome (ARDS) 4. Extracorporeal membrane oxgenation 5. Trans-pulmonary thermodilution monitoring

Exclusion criteria

Exclusion criteria: 1. Pregnant

Design outcomes

Primary

Measure	Time frame
Differences in global end diastolic volume index (GEDVI), extravascular lung water index (EVLWI) and cardiac output (CO), assessed using transpulmonary thermodilution: 1. Between patients with jugular and femoral central venous catheter (CVC) before the initiation of extracorporeal membrane oxygenation (ECMO) 2. Before and during ECMO within groups of patients with jugular and femoral indicator injection	—

Measure

Time frame

Differences in global end diastolic volume index (GEDVI), extravascular lung water index (EVLWI) and cardiac output (CO), assessed using transpulmonary thermodilution: 1. Between patients with jugular and femoral central venous catheter (CVC) before the initiation of extracorporeal membrane oxygenation (ECMO) 2. Before and during ECMO within groups of patients with jugular and femoral indicator injection

—

Secondary

Measure	Time frame
The following are assessed using transpulmonary thermodilution (TPTD) and pulse contour analysis (PCA) 8 hours prior to initiation of ECMO, immediately prior to ECMO, immediately after initiation of ECMO and around 8 hours after ECMO: 1. Comparison of the final ECMO-flow for patients with jugular and femoral group. 2. Comparison of the next-to-last measurements before ECMO and the second TPTDs under the target ECMO-flow. 3. Comparison of the differences of TPTD-values before and during ECMO between the groups with jugular and femoral indicator injection. 4. Analyzing the change in TPTD-values induced by the extracorporeal circuit by multiple regression analysis.	—

Measure

Time frame

The following are assessed using transpulmonary thermodilution (TPTD) and pulse contour analysis (PCA) 8 hours prior to initiation of ECMO, immediately prior to ECMO, immediately after initiation of ECMO and around 8 hours after ECMO: 1. Comparison of the final ECMO-flow for patients with jugular and femoral group. 2. Comparison of the next-to-last measurements before ECMO and the second TPTDs under the target ECMO-flow. 3. Comparison of the differences of TPTD-values before and during ECMO between the groups with jugular and femoral indicator injection. 4. Analyzing the change in TPTD-values induced by the extracorporeal circuit by multiple regression analysis.

—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026