Posttraumatic stress disorder (PTSD) Mental and Behavioural Disorders
Conditions
Interventions
The single-session R-NOT intervention is comprised of two interactive components: a standardised intrusive memory (IM) retrieval procedure followed by inhalation of a premixture of 50% nitrous oxide +
Sponsors
University College London
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–65 years 2.Ability to provide informed consent 3. Meeting DSM-5 criteria for PTSD as determined by the CAPS-5 4. Experiencing =1 distressing intrusive memories per week 5. Sufficient level of English understanding and expression to allow independent completion of assessment instruments and provide written descriptions of memories 6. Access to the internet and a smartphone or similar device on a daily basis 7. Awaiting psychological treatment for PTSD 8. Female participants of childbearing potential (i.e. are not surgically sterilised or postmenopausal) must be willing to use an effective method of contraception (hormonal or barrier method of birth control) or be abstinent from consent to 48 hours after treatment discontinuation
Exclusion criteria
Exclusion criteria: 1. Currently engaged in a psychological therapy for PTSD 2. Change in psychotropic medication in last 4 weeks or planned change during the course of the study 3. Concomitant treatment with ketamine or memantine 4. Recreational use of nitrous oxide more than once in the past 6 months 5. Current alcohol or substance dependence (other than nicotine and caffeine) as suggested by the AUDIT and SDS, and judgement of the team after discussions 6. The diagnostic instrument used to assess depression severity (MADRS) alongside judgement of the team after discussions suggests that depression is the primary diagnosis 7. Current psychosis 8. Active suicide risk 9. Currently participating in another research study or clinical trial related to PTSD, or research that involves a medication 10. Pregnancy or actively attempting to conceive (female participants) 11. Medical contraindications including, but not limited to (at the discretion of the CI/treating clinician): 11.1. Pneumothorax (current or recent ) 11.2. Middle ear disease, infection or recent surgery 11.3. Recent cranial surgery or head trauma 11.4. Respiratory disease (COPD, severe asthma, interstitial lung disease) 11.5. Diagnosed chronic vitamin B12 or folate deficiency 11.6. Risk factors associated with chronic vitamin B12 or folate deficiency without vitamin supplementation (coeliac or inflammatory bowel disease; vegan diet) 11.7. Use of medications known to impair B12 absorption (e.g. metformin, H2-receptor antagonists and proton-pump inhibitors) 11.8. Recent (less than 2 weeks) dental work: extractions, implants, sinus lifts 11.9. Neurological conditions (stroke, encephalopathy, Parkinson’s, brain tumour, multiple sclerosis, poorly controlled epilepsy, dementia or diagnosed cognitive impairment)
Countries
England, United Kingdom
Contacts
Public ContactTallulah Chaplain
Outcome results
None listed