The objective of our study is to characterise the anti-fungal host response (Th17) by fertile and infertile (women and men) couples. Urological and Genital Diseases
Conditions
Interventions
Blood mononuclear cells from fertile and infertile couples will be tested for production of the cytokine IL-17 (hallmark cytokine of the anti-fungal Th17 response) after in vitro stimulation with Cand
Sponsors
ABM UHB NHS Wales UK
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy patients without fertility problem 2. Patients who are under fertility investigation
Exclusion criteria
Exclusion criteria: 1. Pregnant patients 2. Patients diagnosed with HIV or hepatitis 3. Intravenous drug users 4. Individuals unable to provide informed consent 5. Those who have participated in clinical research in the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune response of infertile patients will be evaluated by production of the cytokine IL-17 (hallmark cytokine of the anti-fungal Th17 response) after in vitro stimulation with Candida. | — |
Secondary
| Measure | Time frame |
|---|---|
| The samples (saliva, vaginal swab and semen) also will be assessed for Candida colonization. | — |
Countries
United Kingdom
Outcome results
None listed